Abstract
The solubility of pyrazinamide in twelve pure solvents was measured from 288.15k to 328.15k.The experimental data were correlated by the modified Apelblat model, λh equation, Wilson model and NRTL model, and the modified Apelblat model gave the best satisfactory fitting results. These solubility data of pyrazinamide presented in this paper can provide the basis for the optimization of its crystallization and the preparation of its cocrystals.
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