THE THERAPEUTIC USE OF NITROGEN MUSTARDS

Abstract

Editorial1 October 1947THE THERAPEUTIC USE OF NITROGEN MUSTARDSP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-4-641 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sulfur and nitrogen mustards, because of their use as warfare agents, have been subjected to intensive study, both as to their chemical nature and their action on the tissues. Although originally employed primarily because of their local irritant and vesicant action on the skin and mucous membranes, it was soon recognized that when absorbed they exert a toxic action on a variety of tissues.In animals subjected to toxic doses,1the tissues most severely involved are the mucosa of the gastrointestinal tract and the hemopoietic tissues. There is vacuolization and swelling of the nuclei of the gastrointestinal epithelium, followed...1 GILMANPHILLIPS AFS: The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides, Science, 1946, ciii, 409-415. CrossrefGoogle Scholar2 GOODMAN LS: Nitrogen mustard therapy, Jr. Am. Med. Assoc., 1946, cxxxii, 126-132. CrossrefGoogle Scholar3 JACOBSON LO: Nitrogen mustard therapy, Jr. Am. Med. Assoc., 1946, cxxxii, 263-271. CrossrefGoogle Scholar4 APTHOMASCULLUMBINE MIH: Nitrogen mustards in Hodgkin's disease, Lancet, 1947, i, 899-901. CrossrefGoogle Scholar5 RHOADS CP: Nitrogen mustards in the treatment of neoplastic disease, Jr. Am. Med. Assoc., 1946, cxxxi, 656-658. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDermatology 1 October 1947Volume 27, Issue 4Page: 641-645KeywordsEpitheliumGastrointestinal tractInflammationMucous membranes Issue Published: 1 October 1947 PDF downloadLoading ...