Abstract
Objective To investigate the therapeutic strategy of advanced hilar cholangiocarcinoma and to analyze its prognosis. Methods Retrospective study were performed in 68 patients with advanced hilar cholangiocarcinoma from January 2006 to December 2016, including the record and analysis in terms of gender, age, surgical options, Bismuth-Corlette type, tumor type, differentiation, vascular invasion, lymph node metastasis, oral anticancer drug, operation time, intraoperative blood loss, postoperative chemotherapy and radiotherapy, and the prognosis of patients. Statistical analysis were performed by using SPSS 21.0 software. The risk factors of prognosis were analyzed by using single factor analysis of variance, and multiple factor Logistic regression analysis were carried out on the related factors of advanced hepatic hilar cholangiocarcinoma, and the survival analysis were performed by using Kaplan-Meier method. Results There were significant difference in terms of surgical options, differentiation, vascular invasion, lymph node metastasis, and intraoperative blood loss, in the survival analysis of patients, which showing close correlation of prognosis of patients with advanced hilar cholangiocarcinoma (P<0.05). There were average survival of 35.2 months in R0 resection group, 27.4 months in R1 resection group, 16 months in R2 resection group. 14.6 months in drainage treatment group and 12 months in conservative treatment group. The survival time of the R0 resection group was higher than those of other groups respectively, with significant difference (P<0.05). Conclusion Surgical options, vascular invasion, lymph node metastasis, intraoperative blood loss, differentiation degree have close correlation with prognosis of patients with advanced hilar cholangiocarcinoma. Compared with R1 or R2 resection, drainage or conservative treatment, R0 resection could effectively prolong patients’ survival, is worthy of attention. Key words: Bile Duct Neoplasms; Antineoplastic Protocols; Prognosis
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