Abstract
This review performs a comprehensive assessment of the therapeutic potential of three native herbs of Crete (Thymbra capitata (L.) Cav., Salvia fruticosa Mill. and Origanum dictamnus L.), their phytochemical constituents, health benefits and issues relevant to their safety, within a translational context. Issues discussed comprise: 1) Ethnopharmacological uses of the three herbs, reviewed through an extensive search of the literature; 2) Systematic analysis of the major phytochemical constituents of each plant, and their medicinal properties; 3) To what extent could the existing medicinal properties be combined and produce an additive or synergistic effect; 4) Possible safety issues. We conclude with a specific example of the use of a combination of the essential oils of these plants as an effective anti-viral product and the experience gained in a case of a plant-based pharmaceutical development, by presenting the major steps and the continuum of the translational chain.
Highlights
Plants are traditionally used, in different forms, for the treatment of diseases, since the Neolithic Era (Hardy, 2019)
We have focused on three of the most efficient plants (Coridothymus capitatus, Salvia fruticosa and Origanum dictamnus) and developed a supplement, efficient at combatting upper respiratory tract infections (Duikler et al, 2015; Anastasaki et al, 2017)
Salvia fruticosa is distributed in Italy, Sicily, and the eastern Balkans, including Cyprus, while Origanum dictamnus is local endemic of Crete (Fielding and Turland, 2005)
Summary
In different forms, for the treatment of diseases, since the Neolithic Era (Hardy, 2019). We have focused on three of the most efficient plants (Coridothymus capitatus, Salvia fruticosa and Origanum dictamnus) and developed a supplement, efficient at combatting upper respiratory tract infections (Duikler et al, 2015; Anastasaki et al, 2017). According to the Euro + Med plantbase, Coridothymus capitatus (L.) Reichenb. Accepted name: Thymbra capitata (L.) Cav., Homotypic synonyms: Coridothymus capitatus (L.) Rchb. Calpeana Dautez & Debeaux, Salvia triloba subsp. & Gaill.) Holmboe, Sclarea triloba(L. f.) Raf. Origanum dictamnus L. is a local endemic of Crete, member of Labiatae family. Salvia fruticosa is distributed in Italy, Sicily, and the eastern Balkans, including Cyprus, while Origanum dictamnus is local endemic of Crete (Fielding and Turland, 2005)
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