Abstract
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patien’s median survival rate ranging from 12 to 15 months. Over the last fifteen years, the treatment for GBM has included maximal safe surgical resection with combination radiotherapy and adjuvant temozolomide chemotherapy. The low efficacy of mentioned therapies has forced researchers to explore an appropriate alternative or complementary treatment for GBM. It has been shown that curcumin has therapeutic potentials to fight against GBM via affecting on cell proliferation, apoptosis, cell cycle, invasion and angiogenesis pathways. In addition, curcumin possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as potential therapeutic agent in the treatment of GBM.
Highlights
Минздрава России; Россия, 115478 Москва, Каширское шоссе, 24, стр. 15; 2Институт биохимической технологии и нанотехнологии ФГАОУ ВО «Российский университет дружбы народов»; Россия, 117198 Москва, ул
It has been shown that curcumin has therapeutic potentials to fight against Glioblastoma multiforme (GBM) via affecting on cell proliferation, apoptosis, cell cycle, invasion and angiogenesis pathways
Curcumin possess a synergistic impact with chemotherapeutic agents
Summary
Минздрава России; Россия, 115478 Москва, Каширское шоссе, 24, стр. 15; 2Институт биохимической технологии и нанотехнологии ФГАОУ ВО «Российский университет дружбы народов»; Россия, 117198 Москва, ул. Что куркумин имеет терапевтический потенциал для борьбы с МГБ, воздействуя на пролиферацию клеток, апоптоз, клеточный цикл, инвазию и ангиогенные сигнальные пути. Что куркумин снижает пролиферацию клеток МГБ и их радио- и химиорезистентность.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
