Abstract
Background: Lactobacillus reuteri (L. reuteri) is a probiotic which confers health benefits on the host when administered. The safety and efficacy of L. reuteri in human health and diseases were assessed through this study.
 Objectives: To determine the efficacy of L. reuteri supplement in various diseases.
 Methods: PRISMA guideline was used and systematically searched the Cochrane Library and PubMed electronic databases for studies reporting effects of L. reuteri supplementation consumption in improving patient’s health in different condition/diseases. Twenty-two eligible studies were selected and 1889 patients from general population have been included in our study.
 Results and Discussion: From included studies, the predictive performance of L. reuteri produces significant improvement in treatment of various conditions and diseases. It acts by improving the gut microbiota of several conditions and inflammatory diseases can be managed in a better manner. Supplementation with L. reuteri decreased the severity of various diseases and side effects such as antibiotic associated diarrhea.
 Conclusion: The effect of L. reuteri varies depends on disease condition that was shown in our results. Hence, we conclude that administration of L. reuteri is considered safe and effective when taken as supplementation.
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