Abstract
To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
Highlights
It is accepted that the incidence of cancers of the organs and tissues has increased significantly in recent years throughout the world[1]
MDA levels were significantly decreased, whereas GSH levels, glutathione peroxidase (GPx), CAT, and superoxide dismutase (SOD) activities were significantly increased in uterine tissues in the CYC+CRC and the CYC+CPS groups compared with the control group
The effect of CYC on ovary in the female genital system has been well defined, the effect of CYC on the uterus has not been evaluated. This is the first report to investigate the effects of CYC on the uterus, and this study demonstrated the detrimental effect of CYC on rat uterus by biochemical and histopathological analyses
Summary
It is accepted that the incidence of cancers of the organs and tissues has increased significantly in recent years throughout the world[1]. Adjuvant and/or neoadjuvant chemotherapeutic agents have an essential role in addition to appropriate surgical treatment in cancer therapy. Besides the ability of chemotherapeutic agents to neutralize tumor cells, they have significant adverse effects on many cells in the organism, especially those with anti-mitotic potency[2]. Cyclophosphamide is an alkylating chemotherapeutic agent, and it has an extensive use for adjuvant or neoadjuvant purposes in the treatment of hematological malignancies, neuroblastoma, retinoblastoma, rhabdomyosarcoma, breast, lung, endometrium and ovarian cancers. Catastrophic side effects on the genitourinary, reproductive and gastrointestinal system organs are still not preventable today[3]. While the effect of CYC on ovary in the female genital system has been well described, there is limited data about the effect of CYC on the uterus
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