Abstract
Objective : Cardiovascular disease is amenable to mortality and morbidity in India and worldwide. The asymptomatic nature of hypertension made it a silent killer. Evidence suggests the role of oxidative stress and anxiety in the pathogenesis of hypertension. Lifestyle modification can control hypertension and, thus, can prevent complications. Music therapy is a non-invasive, non-pharmacological, and economic practice used for the management of hypertension, anxiety, and oxidative stress. The present study aims to evaluate the therapeutic effect of Raga Ananda Bhairavi on oxidative stress and anxiety in hypertensive patients.
 Materials and Methods: This randomized control study comprises of a total of 120 participants of age between 30-60years. All the study participants were divided into an experimental and control group. The instrumental music of Raga Ananda Bhairavi was provided to the experimental group for three months. The anthropometric measurements, blood pressure assessment, and estimation of oxidative stress parameters were done in all subjects before and after three months of intervention.
 Results: The systolic blood pressure, diastolic blood pressure, anxiety levels, and oxidative stress marker malondialdehyde significantly reduced after music therapy, and the superoxide dismutase level significantly improved after the intervention.
 Conclusion: Music can be used as an adjunct therapy for the management of hypertension.
Highlights
Hypertension has no warning signs and symptoms until blood pressure levels reach a hostile life stage [1,2]
Hypertension exists as a significant public health problem
The control and management of hypertension are inevitable in the present scenario
Summary
Hypertension has no warning signs and symptoms until blood pressure levels reach a hostile life stage [1,2]. More than 90% of people with high blood pressure are estimated to have essential hypertension [6] Lifestyle modifications and medications can control essential or primary hypertension [2,6,7]. According to updated guidelines on hypertension by Eighth Joint National Committee (JNC-8), Systolic BP ≥140 mm Hg and Diastolic BP ≥90 mm Hg in people less than 60 years should start with antihypertensive medications [8] Hypertension develops when there was the influence of genetic factors, various environmental threats, cigarettes, sedentary lifestyle, overweight, increased salt intake, anxiety, depression as well as in older adults [9]. Humans with hypertension have decreased antioxidant levels and elevated amounts of reactive oxygen species. The imbalance between antioxidants and reactive oxygen species resulted in oxidative stress [11]. Studies revealed that oxidative stress is associated with hypertension [12]. The nonspecific markers of oxidative stress like superoxide and hydrogen peroxide was increased in hypertension [13]
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