Abstract
Objective To study the efficacy and safety of intravesical instillation of OK-432 after resection of superficial bladder tumor.Methods Seventy eight patients of superficial bladder tumor were divided randomly into two groups.OK-432 group:5KE OK-432 was instilled into bladder and retained for 2 hours the first day after operation.The instillation was performed once a week for 6 weeks,and then once a month for 8 months.The control group:30mg Pirarubicin was perfused with the same method as in Group OK-432.Results The patients were followed up for6～36 months,The recurrence rate of primary disease were 2.7%and 10.8%in OK-432 Group and control Group respectively,which had statistical significance(P＜0.05).In patients with the recurrent disease,two groups lowered the recurrence rate but had no statistical significance.multiple,large,sessile and high grade tumors had high recurrence rate.In OK-432 group,patients had good compliance and no side effects,but control Group 7 cases showed up symptoms such as frequent micturition,urgency,urination pain or hematuria,which had statistical significance.Conclusions Intravesical instillation of OK-432 is safe and effective in preventing local recurrence of superficial bladder cancer.it is worth wide clinical application with good compliance and fewer side effects. Key words: Bladder Neoplasms; Perfusion Regional
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