Abstract
Background: Acromegaly defines as chronic elevations of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), which results in enlargement of organs and soft tissues. Cardiovascular complications of acromegaly such as cardiomegaly, hypertension contributing to a high risk of cardiovascular events. This study aimed to identify the determinants of the prevalence of cardiomegaly as cardiovascular comorbidity of acromegaly and the potential effect of the curative intervention. Methods: A total of 160 patients with acromegaly due to pituitary adenoma participated in this study. Acromegaly diagnosed was based on clinical manifestations, age-adjusted plasma IGF-I, and elevated plasma GH levels, not suppressible during an oral glucose tolerance test (75 g). Electrocardiogram and chest X-ray obtained in all patients. Treatment approaches included transsphenoidal surgery and hormonal evaluation performed before and six months after surgery. Results: The GH serum level was elevated in all patients before surgery, with a mean of 33.7 ng/ mL that reached 5.7 ng/mL after surgery. Mean IGF-1 was 794.1 ng/mL that reached 395.6 ng/mL postoperatively. The prevalence of cardiomegaly was 15% that improved in 5% of patients after trans sphenoidal surgery. Conclusion: Appropriate surgical intervention in acromegaly that complicated by cardiomegaly may result in significant improvement of the cardiac structure.
Highlights
Defined as by chronic elevations of insulinlike growth factor-1 (IGF-1) and growth hormone (GH) that results in organomegaly.[1]
There is limited information regarding the effect of surgical resection of pituitary adenoma on cardiovascular comorbidities such as cardiomegaly in patients with acromegaly
All of the patients had a high level of GH and insulin-like growth factor-1 (IGF-1) and, 15 % of them had cardiomegaly that measured by chest X-ray
Summary
Defined as by chronic elevations of insulinlike growth factor-1 (IGF-1) and growth hormone (GH) that results in organomegaly.[1]Due to a higher risk of systemic complications, patients with acromegaly experience increased the rate of morbidity and mortality.[2,3]Cardiovascular manifestations such as congestive heart failure, hypertension, and coronary artery disease are common complications in patients with acromegaly and cause 60% of the deaths in these patients.[4]. Defined as by chronic elevations of insulinlike growth factor-1 (IGF-1) and growth hormone (GH) that results in organomegaly.[1]. Due to a higher risk of systemic complications, patients with acromegaly experience increased the rate of morbidity and mortality.[2,3]. There is limited information regarding the effect of surgical resection of pituitary adenoma on cardiovascular comorbidities such as cardiomegaly in patients with acromegaly. Defines as chronic elevations of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), which results in enlargement of organs and soft tissues. This study aimed to identify the determinants of the prevalence of cardiomegaly as cardiovascular comorbidity of acromegaly and the potential effect of the curative intervention. Conclusion: Appropriate surgical intervention in acromegaly that complicated by cardiomegaly may result in significant improvement of the cardiac structure.
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