Abstract
Artemisinin (ARS) and its derivatives (ARSs) are recommended as the first-line antimalarial drugs for the treatment of malaria. Besides antimalarial function, its potent anti-inflammatory and immunoregulatory properties, as well as the ability to regulate oxidative stress have brought them to a prominent position. As researchers around the world are continually exploring the unknown biological activities of ARS derivatives, experimental studies have shown much progress in renal therapy. This review aims to give a brief overview of the current research on ARSs applications for kidney treatment with the evaluation of therapeutic properties and potential molecular mechanisms.
Highlights
The imbalance between the molecular mechanisms that govern oxidative stress, inflammation, immunity, and cell death are important causes of acute kidney injury (AKI) and chronic kidney diseases (CKD) (Sureshbabu et al, 2015)
It is mainly distributed in the liver, kidney, and bile, and approximately 80% of the drug was excreted through the urine and feces within 24 h of administration (German and Aweeka, 2008; Li, 2012)
Oxidative stress is an important mediator in the development and progression of CKD and AKI and its complications due to increased production of reactive oxygen species (ROS) and diminished antioxidant capacity (Ruiz et al, 2013)
Summary
Edited by: Norberto Perico, Istituto Di Ricerche Farmacologiche Mario Negri, Italy. Reviewed by: Ilse Sofia Daehn, Icahn School of Medicine at Mount Sinai, United States Bente Jespersen, Aarhus University Hospital, Denmark. Artemisinin (ARS) and its derivatives (ARSs) are recommended as the first-line antimalarial drugs for the treatment of malaria. Its potent antiinflammatory and immunoregulatory properties, as well as the ability to regulate oxidative stress have brought them to a prominent position. As researchers around the world are continually exploring the unknown biological activities of ARS derivatives, experimental studies have shown much progress in renal therapy. This review aims to give a brief overview of the current research on ARSs applications for kidney treatment with the evaluation of therapeutic properties and potential molecular mechanisms
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