The Therapeutic Effect of Acanthopanax senticosus Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters.

Chen Song,Sijia Li,Mengyao Liu,Weihong Lu,Ting Ju,Shan Shan,Fangyuan Duan,Yingchun Zhang

doi:10.3390/molecules27031106

Chen Song, Sijia Li + Show 6 more

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https://doi.org/10.3390/molecules27031106

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Abstract

Acanthopanax senticosus (AS) is a medicinal and food homologous plant with many biological activities. In this research, we generated a brain injury model by 60Co -γ ray radiation at 4 Gy, and gavaged adult mice with the extract with AS, Acanthopanax senticocus polysaccharides (ASPS), flavones, syringin and eleutheroside E (EE) to explore the therapeutic effect and metabolic characteristics of AS on the brain injury. Behavioral tests and pathological experiments showed that the AS prevented the irradiated mice from learning and memory ability impairment and protected the neurons of irradiated mice. Meanwhile, the functional components of AS increased the antioxidant activity of irradiated mice. Furthermore, we found the changes of neurotransmitters, especially in the EE and syringin groups. Finally, distribution and pharmacokinetic analysis of AS showed that the functional components, especially EE, could exert their therapeutic effects in brain of irradiated mice. This lays a theoretical foundation for the further research on the treatment of radiation-induced brain injury by AS.

Highlights

Radiation damage to the central nervous system has become an ongoing health challenge of recent decades largely due to the issues of radiation damage occurring duringhuman missions to other planets [1]
We found that the spatial discriminative ability, memory ability and anhedonia of the normal control group were significantly better compared to other groups, indicating that radiation had an irreversible effect on the behavior of mice
Since nerves are sensitive to radiation, we focused on the effects of functional components of Acanthopanax senticosus (AS) on brain injury

Summary

Introduction

Radiation damage to the central nervous system has become an ongoing health challenge of recent decades largely due to the issues of radiation damage occurring duringhuman missions to other planets [1]. Some pharmacological effects of AS, such as immune regulation, and properties, such as anti-radiation and anti-oxidation, have aroused researchers’ interest [4]. In terms of radiation protection, ASPS can reduce oxidative damage caused by radiation through its anti-infective activity [6]. AS has been shown to regulate the process of mediating the excitement and suppression of the central nervous system, and have a good therapeutic effect on related diseases that are caused by decreased learning and memory ability [14]. We isolated the Acanthopanax senticosus polysaccharide (ASPS), flavones, syringin and eleutheroside E (EE) [7]. In this research, we investigated the neuroprotective effects and metabolic characteristics of functional components in AS (ASPS, flavones, syringin, EE) on brain-injured mice

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