Abstract
Living organisms are physical, chemical and biological systems organized in fractal hierarchies of structure and function. Various levels of organization may be the object of study: cell, tissue, organ or whole system. The theory of endobiogeny is a global systems approach to living systems in which the patient as a whole is the object of study. It is a global living systems theory of terrain. The essential activity of the terrain is metabolism: the continuous transformation of energy and matter. According to this theory, the neuroendocrine system is the manager of metabolism and hence the terrain. Modeling the neuroendocrine elements of regulation of the terrain is a key tool in clinical assessment of patients. There are various limits to a strictly quantitative measurement of hormone levels and metabolic activity. Therefore, a modeling system has been developed which uses downstream biomarker output from tissues to assess upstream elements of management of the terrain. This method is called the Biology of Functions. Direct and indirect ratios of biomarkers and indexes have been developed to use quantized data to generate a qualitative analysis of relative capability of the organism. The construction of two direct indexes (genital ratio and genito-thyroid), and one indirect index (evoked histamine) are discussed.
Highlights
The notion of complex systems is ancient
The theory of endobiogeny is a global systems theory of terrain. It evaluates human physiology based on the principles of interrelatedness and integration of various subsystems within the global system
A biological modeling system has been derived called the biology of functions
Summary
The notion of complex systems is ancient. complexity, interrelatedness and coherence were largely expressed in philosophical terms [2]. The third is macro-biochemistry: in vivo output sampling of biological fluids, e.g. prostate specific antigen and urinary electrolytes [12] This allows for quantization of gross metabolic activity through measurement of biomarkers. The fourth is micro-biochemistry, e.g. high throughput metabolomics [13] This allows for massive data acquisition regarding thousands of complex metabolic actions within a single cell. The second is integration of the various quantitative assessments of biological activity in order to generate actionable data at the bedside. The difficulty in this case is that biochemical, biophysical, and metabolic assessments are measured in divergent ways: voltage, osmolality, concentration gradient, compliance, resistance, etc. What is needed in clinical practice is an approach to systems biology based on the whole person, which is quantitative in measurement but qualitative in analysis
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