Abstract
Introduction: The localization of TGR5 in cholangiocytes, the choleretic, anti-inflammatory and anti-apoptotic functions of the receptor suggest that TGR5 is important for the pathogenesis of biliary diseases. Additionally, for the biliary tract disease PSC an association with the frequent TGR5 exon 1 SNP rs11554825 is described, which appears with a lower TGR5 mRNA expression (measured in lymphoblastic cell line) (Hov et al., 2010). Currently no data about TGR5 localization and expression in PSC patients are known. The milieu in PSC livers is insufficiently characterized, but elevated bile salt and cytokine levels are observed in chronic inflammatory bile duct disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
