The test of KIM-1, Cys C and β2-MG to assess the early renal damage in OSAHS patients and its clinical significance

Abstract

Objective:The purpose of this study was to investigate the expression level of kidney injury molecule l (KIM-1), cystatin C (Cys C) and β2-microglobulin (β2-MG) in patients with obstructive sleep apnea and hypopnea syndrome (OSAHS) disease, and to assess the clinical significance among these factors in OSAHS patients with early renal injury.Method:Total 80 OSAHS patients diagnosed by polysomnogram (PSG) in the sleep disorder lab were selected as experimental group and 15 healthy adults who were normal in PSG examinations were selected as control group. Measure the levels of Cys C, β2-MG in fasting venous blood in the morning and detecte the level of KIM-1 in midpiece urine after centrifugation by enzyme-linked immunolsorbent assay (ELISA). All data were analyzed by the SPSS13.0 statistical software.Result:①According to AHI grouping: the average levels of uric KIM-1 in the moderate and severe patients were higher than healthy control group (P< 0.01). The serum levels of Cys C and β2-MG in severe OSAHS patients were higher than healthy control group (P< 0.01). Besides, the difference of the average levels of uric KIM-1 among the mild, moderate and severe OSAHS patients was statistically significant (P< 0.01) and the serum level of Cys C and β2-MG only in severe OSAHS patients were higher than mild and moderate OSAHS patients (P< 0.01). ②According to LSaO₂ grouping: the average level of KIM-1, Cys C and β2-MG in the severe group were higher than normal control group (P< 0.01). Besides, the average level of KIM-1, Cys C and β2-MG in severe group were higher than mild and moderate groups (P< 0.01). ③KIM-1, Cys C and β2-MG were positive correlated with each other and AHI (P< 0.01). ④KIM-1, Cys C and β2-MG were negative correlated with LSaO₂ (P< 0.01). Conclusion:The urine level of KIM-1 might be a sensitive indicator in OSAHS patients with early renal damage. It was better to evaluate renal injury by AHI grouping than LSaO₂ in OSAHS patients.