Abstract
β-Momorcharin is a basic glycoprotein found in the seeds of Momordica charantia L. It differed immunologically from α-momorcharin also of the same source but possessed similar midterm abortifacient activity. Intraperitoneal administration of β-momocharin into mice on Days 4 and 6 of pregnancy led to an inhibition of pregnancy. In vitro study showed that the protein disturbed peri-implantation development by: (a) blocking the hatching of embryos from the zona pellucida; (b) decreasing the incidence of successful attachment of the blastocyst; (c) reducing the trophoblast outgrowth; and (d) disrupting the development of inner cell mass. It is likely that β-momorcharin inhibited embryonic implantation by a similar biological action previously described for α-momorcharin.
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