Abstract
The teratogenic potential of D & C Yellow No. 8, sodium fluorescein (C.I. No. 45350, CAS No. 518-47-8) was determined in rats and rabbits. An aqueous solution of the dye was administered by gavage to groups of 25 Charles River Sprague-Dawley rats at doses of 100, 500 and 1500 mg/kg on days 6–19 of gestation and to groups of 14 Dutch Belted rabbits at doses of 30, 100 and 250 mg/kg on days 6–27 of gestation. These doses did not result in evidence of maternal toxicity or adverse effects on foetal development.
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