Abstract
BackgroundChina is experiencing rapid age, which will lead to increasing burden of age-related diseases, such as Alzheimer disease and other forms of dementia.ObjectivesThe aim of this study was to 1) Explore the temporal trend of mortality of Alzheimer disease (AD) and other forms of dementia in China and 2) Analyze its geographic variations and urban-rural differences and calculate the years of life lost (YLLs) from AD and other forms of dementia.Data and methodsData were extracted from the National Mortality Surveillance System (NMS). Age-standardized mortalities were calculated with the Western Grade 26 Standard Life List, and the YLLs were calculated using the DALY template provided by the WHO / World Bank global burden of disease (GBD) Working Group. The trends in crude and age-standardized mortality of AD and other forms of dementia were examined using Cochran-Armitage trend test.ResultsIn China, the crude mortality from AD and other forms of dementia increased from 2009 to 2015, but the age-standardized mortality decreased. The YLLs of AD and other forms of dementia increased during the study period. The age-standardized mortality in the east was higher than those in the west and middle regions, and the age-standardized mortality in rural areas was higher than that in urban areas.ConclusionIn China, the age-standardized mortality of AD and other forms of dementia decreased from 2009 to 2015. However, the disease burden from AD and other forms of dementia is becoming heavier due to increasing elderly population. Moreover, there were geographic variations and urban-rural differences in mortality of AD and other forms of dementia in China.
Highlights
With progressively aging populations around the world, dementia, a clinical syndrome of cognitive impairment or recession highly correlated with age, has severely impacted individuals, families, and societies[1]
Age-standardized mortalities were calculated with the Western Grade 26 Standard Life List, and the years of life lost (YLL) were calculated using the DALY template provided by the WHO / World Bank global burden of disease (GBD) Working Group
The YLLs of AD and other forms of dementia increased during the study period
Summary
With progressively aging populations around the world, dementia, a clinical syndrome of cognitive impairment or recession highly correlated with age, has severely impacted individuals, families, and societies[1]. The World Alzheimer Report 2016 estimated a global prevalence of people living with dementia of 47 million people, which is projected to almost increase to 74.7 million in 2030 and 131 million in 2050[2]. Dementia is a more serious public health problem in low and middle-income countries (LMICs). According to World Bank classification in 2015, 58% of all people with dementia live in LMIC, a proportion which is projected to rise to 63% in 2030 and 68% in 2050[WHO 2015]. World Alzheimer Report 2016 estimated that the cost of supporting dementia worldwide is US $818 billion and will reach a trillion US dollar by 2018[2]. China is experiencing rapid age, which will lead to increasing burden of age-related diseases, such as Alzheimer disease and other forms of dementia
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