Abstract
Cytoplasmic RNA from cells infected at the restrictive temperature with temperature-sensitive mutants of SV40 has been analyzed by annealing to the separated strands of SV40 DNA. D mutant virions make very little (if any) viral-specific RNA. A mutants make significant amounts of early but not late SV40 RNA. B mutants make both early and late viral RNA. M-band analyses following infection with prelabeled virions suggest that D mutant virions do not form viral DNA-nuclear membrane complexes, whereas those formed by A mutants are normal. Nascent viral DNA is normally released from A mutant complexes at the restrictive temperature.
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