Abstract
BackgroundTCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D).MethodsThe SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent.ResultsThis study found no T1D association with, and no age-of-onset effect from rs7903146.ConclusionThis study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.
Highlights
transcription factor 7-like 2 (TCF7L2) belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3
This study suggests that a type 2 diabetes (T2D) mechanism mediated by TCF7L2 does not participate in the etiology of type 1 diabetes (T1D)
TCF7L2 belongs to a subfamily of TCF7like HMG box-containing transcription factors, and maps to human chromosome 10q25.3[13]. It is a component of the Wnt signaling pathway, and participates in the tissuespecific regulation of expression of proglucagon gene, which has been shown critical in blood glucose homeostasis[14]
Summary
TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D). TCF7L2 belongs to a subfamily of TCF7like HMG box-containing transcription factors, and maps to human chromosome 10q25.3[13]. It is a component of the Wnt signaling pathway, and participates in the tissuespecific regulation of expression of proglucagon gene, which has been shown critical in blood glucose homeostasis[14]. To investigate the possibility of this association, we genotyped the marker most significantly associated with T2D, the intronic SNP rs7903146, in our T1D family collection
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