Abstract
We describe a virus isolated from Culex annulirostris mosquitoes in Australia. Phylogenetic analysis of its RNA-dependent RNA polymerase sequence and that of other related viruses revealed 6 clades, two of which corresponded wholly or partly with existing genera in the family Nodaviridae. There was greater genetic diversity within the family than previously recognized prompting us to suggest that additional genera should be considered within the family.
Highlights
Nodaviruses are positive-sense RNA viruses with bipartite genomes which are capped but not polyadenylated [1]
The earliest isolations were of the alphanodaviruses in Australasia, initially with Nodamura virus (NoV) in Japan [2]; Flock House virus (FHV), and Black beetle virus (BBV), and Boolarra virus (BoV) [3]
Clade 1 corresponded to the alphanodaviruses with the notable omission of Pariacoto virus (PaV)
Summary
Nodaviruses are positive-sense RNA viruses with bipartite genomes which are capped but not polyadenylated [1]. There are currently two genera recognized: Alphanodavirus (5 species) and Betanodavirus (4 species). Pariacoto virus (PaV) [4] was isolated from a sample from Peru; the first alphanodavirus identified outside Australasia. The four recognized species in the betanodaviruses are Barfin flounder nervous necrosis virus (BFNNV), Redspotted grouper nervous necrosis virus (RGNNV), Striped jack nervous necrosis virus (SJNNV), and Tiger puffer nervous necrosis virus (TPNNV) [3]. In 2014, a nodavirus named mosinovirus (MoNV) was isolated from mosquito species of the Culex genus [5]. MoNV is not yet recognized as a species and has not been assigned to a genus. A large number of nodavirus-like sequences were identified in a large-scale sequencing study of invertebrates [6]. This study has greatly enlarged our knowledge of the genetic diversity of this group of viruses, and will be complemented by future research on their biology
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
