Abstract
The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media. The prospective study included a group of 60 patients with different forms of chronic suppurative otitis media (CSOM), cholesteatoma recidivism and a control group of 30 healthy people. The total antioxidant capacity (TAC) and malondialdehyde (MDA) concentrations were determined in serum of thepatients. We noticed a significant lower mean of TAC levels (p[ 0.001) in patients with chronic suppurative otitis media (CSOM) with and without cholesteatoma compared to the control group. The MDA had significantly higher mean values (p[ 0.001) compared to the healthy group.The imbalance of antioxidant systems to oxidizing molecules plays an important role in the pathogenesis of CSOM with and without cholesteatoma.
Highlights
The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media
total antioxidant capacity (TAC) levels in the study group varied between 25.902 mmol/μL and 28.411 mmol/μL in patients with cholesteatoma recidivism, 26.908 mmol/μL and 28.608 mmol/μL in patients with chronic suppurative otitis media (CSOM) with clinic and radiologic cholesteatoma and 25.815 mmol/μL and 29.313 mmol/μL in patients with CSOM without cholesteatoma
TAC values ranged between 27.834 mmol/μL and 31.185 mmol/μl with a mean of 29.401 mmol/μL
Summary
The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media. The prospective study included a group of 60 patients with different forms of chronic suppurative otitis media (CSOM), cholesteatoma recidivism and a control group of 30 healthy people. We noticed a significant lower mean of TAC levels (p< 0.001) in patients with chronic suppurative otitis media (CSOM) with and without cholesteatoma compared to the control group. There is an acceleration of reactive oxygen species (ROS) formation, resulting in an imbalance between oxidative factors and protective antioxidant systems. This explains the involvement of free radicals in many diseases: respiratory diseases, kidney problems, hypertension, neuro-degenerative diseases (Alzheimer’s, Parkinson’s), diabetes, asthma, carcinogenesis, inflammatory rheumatic diseases, cataract and macular degeneration [4, 5]. Cellular targets for free radical actions include lipids, macromolecules, proteins and DNA [7]
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