The t-Distribution Approach to the Second-Order Multiresponse Surface Model of Paracetamol Tablets Quality Characteristics

Abstract

The normal distribution approach is often used in regression analysis at the Response Surface Methodology (RSM) modeling stage. Several studies have shown that the normal distribution approach has drawbacks compared to the more robust t-distribution approach. The t-distribution approach is found to control size much more successfully in small samples compared to existing methods in the presence of moderately heavy tails. In many RSM applications, there is more than one response (multiresponse), which is usually correlated with each other (multivariate). On the other hand, the actual response surface habitually indicates the curve by the optimal value, so the second-order model is used. This paper aims to develop the second-order multiresponse surface model using a multivariate t-distribution approach. This work also provides the parameter estimation procedure and hypothesis testing for the significance of the parameter. First, the parameter estimation is performed using the Maximum Likelihood Estimation (MLE), followed by the Expectation–Maximization algorithm as an iterative method to find (local) maximum likelihood. Next, the Likelihood Ratio Test (LRT) method is used to test the parameters simultaneously. The model obtained uses this approach to determine the conditions of input variables that optimize the Paracetamol tablets’ physical quality characteristics.