Abstract
Background and aimsInflammation plays a key role in the initiation and progression of atrial fibrillation (AF). The systemic inflammation indexes are easily evaluated and predict AF development. However, it’s role in prediction of recurrence of AF is unknown. We aim to explore the association between the systemic inflammation indexes and recurrence of AF in patients underwent cryoablation (CryoMaze) concomitant with mitral valve surgery.MethodsWe examined systemic inflammation indexes during perioperative period in 122 patients between 2015 and 2018. Systemic inflammation indexes were developed by systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocytes to monocytes ratio. Univariate and multivariate analyses were performed to examine the association of each markers with recurrence of AF.ResultsOf the 122 patients included in this study, 22 patients (18%) experienced AF recurrence after CryoMaze concomitant with mitral valve surgery. There is no significant difference between each systemic inflammation indexes before surgery and recurrence of AF. In univariate analysis, MLR after surgery 3 days, PLR, MPLR, NLR, SII after surgery 7 days were able to predict recurrence of AF. In multivariate analyses, SII ≥ 1696 independently predicted recurrence (OR, 3.719; 95% CI, 1.417–9.760). Interestingly, baseline SII showed no significant in prediction of recurrence. It was sharply elevated after surgery and dropped slowly. In patients of recurrence, SII after 7 days of surgery increased again.ConclusionsThe raised SII again was associated with an increased risk of the postoperative recurrence of AF and independently predicted the late recurrence of AF after CryoMaze concomitant with mitral valve surgery.
Highlights
Atrial fibrillation (AF) is a common arrhythmia associated with mitral valve disease
Systemic inflammation indexes were developed by systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocytes to monocytes ratio
Of the 122 patients included in this study, 22 patients (18%) experienced atrial fibrillation (AF) recurrence after CryoMaze concomitant with mitral valve surgery
Summary
Atrial fibrillation (AF) is a common arrhythmia associated with mitral valve disease. Half of patients undergoing mitral valve surgery frequently present with AF, which is associated with poor prognosis [1]. Luo et al BMC Cardiovascular Disorders (2022) 22:45 cryoablation (CryoMaze) concomitant with mitral valve surgery was achieved in 85% (95% CI, 0.76–0.91) [5]. Systemic immune-inflammation index (SII) is a novel marker that brings together these three inflammatory peripheral cell counts and predict functionally significant coronary artery stenosis [14,15,16]. We investigated the association of perioperative systemic inflammation index, and changes during treatment, with outcomes in AF patients treated with CryoMaze concomitant with mitral valve surgery. We aim to explore the association between the systemic inflammation indexes and recurrence of AF in patients underwent cryoablation (CryoMaze) concomitant with mitral valve surgery
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