The systemic lupus erythematous in paediatrics: Moroccan experience of a unit of pediatric rheumatology

Abstract

Results The clinical picture showed fever in 76.66% of patients, the frequency of joint locations (90%), skin (86.66%), kidney (66.6%) , hematologic (50%) lung (36.66%), gastrointestinal (30%), neuropsychiatric (26.66%) and cardiac (23.3%) involvement. The hematological involvement was detected in 76.66% of our patients, an inflammatory syndrome in 83.33%, immunological disturbances with positive titers of anti- DNAN AC (90%) , ANA (93.6%), and a reduction of the complement (83.33%) . False syphilis serology completed by anti b2Glycoprotein1 antibodies (26%) and anti- cardiolopine were positive in respectively 40, 26 and 20% of cases. Renal involvement is manifested by renal insufficiency in 43% of cases, a significant proteinuria in 50% of cases and prevalence of class IV on biopsy. A case of kikushi fujimoto has been reported as 5 hemophagocytic syndromes. All patients were treated with systemic corticosteroids and hydroxychloroquine. The use of methylprednisolone bolus was indicated in cases of SAM or severe renal impairment associated with cyclophosphamide / MMF and anti-proteinuric medication. Conclusion The prognosis of pediatric SLE remains unpredictable; however it is attached to the renal, neurological and the occurrence of MAS. We mourn two deaths one by neurological attack and other by renal failure.