Abstract
BackgroundKashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare. We performed an initial systematic review and meta-analysis to assess the X-ray detective rate of KBD in China.MethodsFor this systematic review and meta-analysis, we searched five databases (PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WanFang Data and the China Science and Technology Journal Database (VIP))using a comprehensive search strategy to identify studies of KBD X-ray detective rate in China that were published from database inception to January 13, 2018. The X-ray detective rate of KBD was determined via an analysis of published studies using a random effect meta-analysis with the proportions approach. Subgroup analysis and meta-regression were used to explore heterogeneity, and study quality was assessed using the risk of bias tool.ResultsA total of 53 studies involving 14,039 samples with X-ray detective rate in 163,340 observations in total were included in this meta-analysis. These studies were geographically diverse (3 endemic areas). The pooled overall X-ray detective rate for KBD was 11% (95%CI,8–15%;Z = 13.14; p < 0.001). The pooled X-ray detective rate estimates were 11% (95%CI, 6–17%; Z = 7.06; p < 0.001) for northeast endemic areas, 13% (95%CI, 7–20%; Z = 7.45; p < 0.001) for northwest endemic areas, and 8% (95%CI, 5–12%; Z = 7.90; p < 0.001) for southwest endemic areas. There was a significant relationship between the survey year and the X-ray detective rate of KBD.ConclusionsOur systematic review found that the summary estimate of the X-ray detective rate of KBD was 11% and, that KBD X-ray positive rate ranged from 8.00 to 15.00% depending on the study. Further research is required to identify effective strategies for preventing and treating KBD.
Highlights
Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease
In another analysis of national surveillance on KBD condition from 2000 to 2007, Liu et al showed that the average X-ray detective rate of KBD in west endemic region has decreased from 21.75% in 2000 to 7.30% in 2007 [6]
Meta-analysis The overall estimated X-ray detective rate of KBD was 11% (95%confidence interval (CI),8–15%;Z = 13.14; p < 0.001)
Summary
Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. Kashin-Beck disease (KBD) is a serious, endemic chronic osteochondral disease in humans that is distributed from northeast to southwest China, affecting 378 counties in 13 provinces [1]. KBD is a major public health problem that results in serious health consequences for patients, including symmetrical enlargement of the phalanges, brachydactyly, joint deformity, and even dwarfism [3], which leads most patients with KBD to partially or completely lose their working capacity and self-care abilities. According to reports of a national survey of KBD prevalence in 2005 [5], National KBD surveillance group found that the X-ray detective rate of KBD was less than 3.00% in the east part of endemic region and was more than 10% in the west part of endemic region, some endemic region in west were 25%. A number of controversies remain related to estimating the X-ray detective rate of KBD
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