Abstract
Abstract In connection with work underway in these laboratories on the total synthesis of Pentacyciic. triterpenes; guitable methods were sought for the introduction of angular methyl groups into preiormed polynuclear systems. A method of some generality was recognized in the work ofNagata3 on the organoaluminum catalyzed conjugate addition of cyanide to α,β-unsaturated ketones and subsequent conversion of the resulting cyano group to the desired angular methyl substttuent. The total synthesis of dl-alnusenone reported4a earlier from these laboratories has this synthon as its central feature. Another approach that appeared attractive entailed the 1,6-addition 5 of cyanide to the dienone 1, available from intermediates already in hand.4b
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