Abstract
ABSTRACTThe β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
Highlights
IntroductionThe copolymer could increase the solubility of Methyl-2-benzimidazolecarbamate (MBC) and Natamycin (NM) and the stability constant of MBC·CD maleate (CDM)-AM complex and NM·CDM-AM complex were 3000.89 M−1 and 10,725.45 M−1, respectively [8]
The aim of this work was to synthesize the water soluble cyclodextrin copolymer by radical polymerization initialized by γ-ray, and form the inclusion complexes with hydrophobic drugs, NM and MBC
CD maleate (CDM) was prepared via the semi-dry reaction method which was reported in our former research [11]. β-CD (6 mmol) was mixed with maleic acid (24 mmol), Sodium hypophosphite monohydrate (SHP) (6 mmol) and 4-methoxyphenol (0.6 mmol) in a pressure bottle
Summary
The copolymer could increase the solubility of Methyl-2-benzimidazolecarbamate (MBC) and Natamycin (NM) and the stability constant of MBC·CDM-AM complex and NM·CDM-AM complex were 3000.89 M−1 and 10,725.45 M−1, respectively [8]. Compared to the traditional technology of polymerization method, it has many advantages in improving the polymer performance, such as high grafting rate, no harmful chemical residue, no selectivity to substance and so on. Irradiation polymerization has not been reported in the preparation of cyclodextrin polymer before. The aim of this work was to synthesize the water soluble cyclodextrin copolymer by radical polymerization initialized by γ-ray, and form the inclusion complexes with hydrophobic drugs, NM and MBC. The difference of CDM-AM copolymers synthesized by irradiation and chemical initiator were compared in this article.
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