Abstract
The synthesis of the adenine derivative (±)-(1α,2β,4α)-4-(6-amino-9H-purin-9-yl)-1,2-cyclopentanediol ( 2) and its hypoxanthine analogue ( 3) as carbocyclic nucleosides lacking the 5′-methylene is described in 7 steps from 3-cyclopenten-1-ylamine hydrochloride ( 4) in on overall yield of 30% for 2 and 27% for 3.
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