Abstract
We report the first synthesis of the antibacterial peptide Kawaguchipeptin B. This was carried out on 11 different polystyrene resins ranging from 0.3 to 6.0% DVB cross-linking. The synthesis was accomplished using an Fmoc/ t Bu/Aloc strategy, with side chain resin attachment and a C-terminal allyl ester group for cyclisation. The syntheses of the linear and cyclic forms of the peptide were monitored and surprisingly showed that synthetic efficiency increased with increasing resin-cross linking.
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