Abstract
AbstractThe syntheses of 1,2,3,4,10,14b‐hexahydro‐2‐methylpyrazino[2,1‐a]pyrido [2,3‐c][2]benzazepine (Org 3770) labelled with 3H (and 2H), 13C and 14C are described. Tritiated Org 3770 was prepared either by exchange under alkaline conditions with tritiated water or catalytic reductive dehalogenation of a chloro analogue with 3H2. 13C‐labelled material was obtained in a seven‐step synthesis starting from 13C‐labelled benzene whereas 14C‐Org 3770 was prepared in a three‐step synthesis starting with 14CO2. All labelled compounds were analyzed by TLC, HPLC, MS and NMR.
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