The synthesis of novel piperazine-benzodioxole substituted phthalocyanines and investigation of their α-amylase and tyrosinase inhibition properties

Abstract

In this study, novel 1-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine substituted phthalocyanine Zn(II), Pb(II) and Co(II) complexes (ZnPc, PbPc, CoPc) were synthesized and proposed structures were confirmed by FT-IR, NMR, UV–vis and MS instrumental techniques. The inhibition potentials of these newly synthesized Pc compounds on, α-amylase and tyrosinase enzymes were investigated. PbPc molecule was found to be most active against α-amylase (IC50 value 7.3 ± 0.3 µM) and tyrosinase (IC50 value 6.7 ± 0.6 µM). Kinetic studies showed that the inhibition mechanism of PbPc molecule on tyrosinase and α-amylase activity was mixed-type.