The synthesis of new potential photosensitizers [1–3]. Part 4. Photophysical properties of some monophenyltripyridyl-porphyrin derivatives

Abstract

Six monophenyltripyridylporphyrin derivatives were synthesized and characterized by spectroscopy in order to demonstrate their potential usefulness as photosensitizers for anticancer therapy purposes. Compounds 1 and 3–5 are amphiphilic, thus they may be suitable for transfer inside cells. Photochemical parameters such as fluorescence yield and singlet oxygen yield were determined. The former parameter does not exceed 10% which makes them unsuitable for photodynamic diagnosis (PDD). However, singlet oxygen yields are high and sufficient for these compounds to be considered as potential photodynamic therapy (PDT) photosensitizers.