Abstract
Treatment of easily available ketone‐derived cyanoamides with NaOtBu leads to enamides in a simple, scalable, and inexpensive one‐step operation in good yield. Enamides not stabilized by conjugation or by inclusion in a ring can also be prepared. An E1cB mechanism consistent with all results and observations, is proposed. The Z geometry of the product enamide is highly favoured, and the regioselectivity can be directed by one′s choice of protecting group.
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