Abstract
ABSTRACTBioadhesives or surgical adhesives are an attractive and alternative material for suturing or stapling. The fibrin‐based and cyanoacrylate adhesives are mostly used nowadays, but they still have some problems that are difficult to solve. The urethane‐based adhesive has been considered as the most promising material because they are biocompatible and able to react with the amine groups of proteins on the living tissues. Its curing is, however, not satisfactory due to the aliphatic isocyanates used for its biocompatibility. Therefore, in this work, l‐3,4‐dihydroxyphenylalanine (l‐DOPA) as a third component from mussel's adhesive proteins was introduced to the urethane prepolymer to enhance the adhesive ability through a series of chemical reactions such as esterification, amidation, and handling of protection groups. Demethylation with two different experimental conditions was also evaluated. © 2013 Wiley Periodicals, Inc. Adv Polym Technol 2013, 32, 21338; View this article online at wileyonlinelibrary.com. DOI 10.1002/adv.21338
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