Abstract

A synthetic methodology for the synthesis of 13,14-seco-steroids with substituents at C-14 and C-17 is described. The approach involves Grob fragmentation of 14β-hydroxy-17β-tosylates, hydroboration–oxidation of the intermediate Δ 13(17)-olefin, and hydride reduction of the 14-ketone. An unambiguous structural assignment of (13 R,14 S,17 S)-14,17-diacetoxy-3-methoxy-7α-methyl-13,14-secoestra-1,3,5(10)-triene was determined by X-ray analysis.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.