Abstract
Methods for the synthesis and purification of fluorescent penicilloyl haptens are presented. These haptens combine specifically with anti-penicilloyl antibodies from rabbits or humans and can be used to determine antibody concentration and binding affinity by fluorescence polarization. Large differences in binding affinity have been found in the antibodies from different human sera. These results suggest a detailed study of antibody parameters in the various immunoglobulin fractions as related to clinical symptoms of penicillin allergy.
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