Abstract
Two comb-like polymeric prodrugs of 5-fluorouracil derivatives (p(MAA-PEG400-5Fu), p(MAA-PEG2000-5Fu)) were synthesized from monomers, methacryloyl (polyethylene glycol 5-fluorouracil acetyl) (MAA-PEG-5Fu) through radical polymerization using azobisisobutyronitrile (AIBN) as initiator in N,N-dimethyl formamide solution, which structures were confirmed by means of IR, 1HNMR, UV-Vis, MS and GPC spectroscopy. The drug loading rates of the two prodrugs (p(MAA-PEG400-5Fu), p(MAA-PEG2000-5Fu)) were 25.51%, 10%, respectively.
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