The synthesis of chemotherapeutic agents. I.: The synthesis of certain thio and dithio compounds

Abstract

Investigation of 5,5′-diacetamido-8,8′-diquinolyl disulfide indicated that it possesses a relatively high antimalarial activity. The report of this activity stimulated interest in the possible chemotherapeutic value of certain related thio and dithio compounds. This paper, the first of a series, describes the synthesis of sixteen compounds, eight of which are new, related to 5,5′-diacetamido-8,8′-diquinolyl disulfide. Twelve of these compounds were tested for antimalarial activity and the results of these tests are tabulated. In addition some of the compounds were also subjected to screening tests against Trypanosoma brucei, influenza virus and tetanus toxin.