Abstract
Abstract: Natural products are important from researchers’ perspectives due to their importance and applicability. Polyhydroxylated pyrrolizidine alkaloids are sugar mimics and received a growing interest in the last few years. Australine is a naturally polyhydroxylated pyrrolizidine, which was isolated from the seeds of Castanospermum austral, and exhibits potent biological activities such as inhibited glycosidases, as well as anti-virus, and anti-HIV activities. Thus, there is a considerable deal of interest in the synthesis of these classes of compounds. Different synthetic strategies and methodologies for the preparation of Australine and its stereoisomers were considered.
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