Abstract
New 11C-labelled precursors [1- 11C]ethyl, [1- 11C]propyl, [1- 11C]butyl, and [1- 11C]isobutyl iodides have been prepared by a 3-step reaction route using a one-pot system. The labelled iodides were obtained in 20–55% radiochemical yields and 65–95% radiochemical purities, with a total time for synthesis of the order of 10–14 min. The labelled iodides have been used in alkylation reactions with nitrogen, oxygen and carbon nucleophiles. The nitrogen alkylation reactions are exemplified by the synthesis of the analgetics N-[1- 11C-ethyl]lidocaine and N-[1- 11C-butyl]bupivacaine. The synthesis of 3-nitrophenyl[1- 11C]propyl ether is also presented in this paper as an example of an oxygen alkylation.
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Schedule a callMore From: International Journal of Radiation Applications & Instrumentation. Part A, Applied Radiation & Isotopes
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