The synthesis, metallation and functionalization of bromo- F-menthyl diphenylphosphine oxide

Abstract

Bromo- F -methyl diphenylphosphine oxide is conveniently prepared via reaction of bromo- F -methane and ethyl diphenylphosphinite. Metallation with zinc provides a stable organozinc derivative in high yield. ▪ This organozinc compound provides a useful synthetic intermediate for the introduction of the F -methylene diphenylphosphine oxide group into organic compounds. Reaction with trivalent phosphorus derivatives gives the mixed P(V)-P(III) compounds; further oxidation ▪ gives the P(V)-P(V) derivatives. The synthesis and functionalization of this new organozinc compound will be discussed.