Abstract
Neurotoxic warfare chemical agents (CWA/NA) induce major toxicological effects to the affected personnel. Their increased toxicity justifies the necessity of developing analytical methods for diagnosis and specific medical counter measures. CWA/NA are extremely toxic agents which are subject to international regulations (The Geneva Protocol regarding the prohibition of chemical weapons). Taking into account the ban on human experimenting due to high toxicity, simulators of neurotoxic chemical agents are being used in laboratories. These are analogue chemical compounds which possess the same relevant physical, chemical and pharmacodynamical properties of the corresponding agents, but with lower intrinsical toxicity. The synthesis and toxicological characterization of these simulators of neurotoxic chemical agents allow the laboratory research of these extremely toxic compounds and the unfolding of risk-free antidote studies. This paper proposes the synthesis and toxicological testing of chemical compounds which simulate sarin (4-nitrophenyl isopropyl methylphosphonate - NIMP) and VX (4-nitrophenyl ethyl methylphosphonate - NEMP).
Highlights
Neurotoxic warfare chemical agents (CWA/NA) induce major toxicological effects to the affected personnel
This paper proposes the synthesis and toxicological testing of chemical compounds which simulate sarin (4nitrophenyl isopropyl methylphosphonate - nitrophenyl isopropylic methylphosphonate (NIMP)) and VX (4-nitrophenyl ethyl methylphosphonate - NEMP)
High-risk neurotoxic chemical agents are extremely toxic compounds which have structures of phosphoric acid esters [1-8]. Due to their extremely high toxicity, they were registered on the list of substances which must be destroyed according to the international regulations (Convention on the Prohibition of the Development, Production and Stockpiling of Chemical Weapons)
Summary
The chemical compounds that were identified as possible simulators of neurotoxic agents, necessary in research activity regarding the optimization of specific treatment in the intoxication with neurotoxic organophosphoric compounds, are the non-volatile compunds: 4-nitrophenyl isopropylic methylphosphonate (NIMP) for sarin and 4-nitrophenyl ethyl methylphosphonate (NEMP) for VX. These maintain, within their molecule, the active group F-P=O which is responsible for the toxicological properties.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
