Abstract

An improved synthesis of (22 R)-20α,22- and (22 S)-20α,22-dihydroxycholesterol from pregnenolone acetate is described and the stereochemistry at C-20 and C-22 established. The title compounds have been labeled at C-1 and C-2, using 20α-hydroxycholesta-1,4-diene-3,22-dione as starting material.

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