Abstract
The derivatives of 3‐formyl‐2(1H)‐quinolones and N‐methyl‐3‐formyl‐2‐quinolones substituted in the 6‐position with either a methyl or a methoxy group were synthesised and evaluated as potential sensors for the detection of thiol amino acids. Their spectroscopic properties, including absorption and emission spectra, fluorescence quantum yields and singlet lifetimes, were examined. The behaviour of the obtained compounds was studied at pH 7.4 in the presence of various amino acids. The results show that these compounds demonstrate a high turn‐off fluorescence response and selectivity toward L‐cysteine in the presence of other amino acids, and have the potential to act as sensors to L‐cysteine.
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