Abstract
The dipeptidyl phosphonamidate analogues ( 3)-( 12) inhibited a range of serine β-lactamases, being most efficacious against the Enterobacter cloacae P99 isolated enzyme. Synergy experiments demonstrated that the antibacterial activity of amoxycillin is potentiated against bacteria producing these enzymes, the effect again being most pronounced against the P99-producing E.cloacae N-1 strain. The analogues ( 11) and ( 12) (β-amino acid C-terminal) were the most active inhibitors and synergists.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
