Abstract
The synthesis of (±)-epiquinamide 1 and (±)- C(1)- epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [ 3H]epibatidine binding to rat brain membranes neither (±)- 1 nor (±)- 2 showed any significant level of nicotinic activity.
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