The synthesis and characterization of monodispersed chitosan-coated Fe3O4 nanoparticles via a facile one-step solvothermal process for adsorption of bovine serum albumin.

Mao Shen,Wenping Jia,Ying Min Jin,Guang Chen,Yujing Yu,Guodong Fan,Wenyuan Tang

doi:10.1186/1556-276x-9-296

Abstract

Preparation of magnetic nanoparticles coated with chitosan (CS-coated Fe3O4 NPs) in one step by the solvothermal method in the presence of different amounts of added chitosan is reported here. The magnetic property of the obtained magnetic composite nanoparticles was confirmed by X-ray diffraction (XRD) and magnetic measurements (VSM). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) allowed the identification of spherical nanoparticles with about 150 nm in average diameter. Characterization of the products by Fourier transform infrared spectroscopy (FTIR) demonstrated that CS-coated Fe3O4 NPs were obtained. Chitosan content in the obtained nanocomposites was estimated by thermogravimetric analysis (TGA). The adsorption properties of the CS-coated Fe3O4 NPs for bovine serum albumin (BSA) were investigated under different concentrations of BSA. Compared with naked Fe3O4 nanoparticles, the CS-coated Fe3O4 NPs showed a higher BSA adsorption capacity (96.5 mg/g) and a fast adsorption rate (45 min) in aqueous solutions. This work demonstrates that the prepared magnetic nanoparticles have promising applications in enzyme and protein immobilization.

Highlights

In the past several decades, magnetic nanomaterials of iron oxides (Fe3O4 NPs) have attracted much research interest due to their potential applications in magnetic storage, catalysis, electrochemistry, drug delivery, medical diagnostics, and therapeutics based on their unique magnetic, physiochemical, and optical properties [1,2,3,4,5]
There are very few reports on the synthesis of magnetic nanoparticles coated with chitosan (CScoated Fe3O4 NPs) by a one-step solvothermal process
We report the preparation of monodispersed CS-coated Fe3O4 NPs in the presence of different amounts of added chitosan via a facile one-step solvothermal process

Summary

Introduction

In the past several decades, magnetic nanomaterials of iron oxides (Fe3O4 NPs) have attracted much research interest due to their potential applications in magnetic storage, catalysis, electrochemistry, drug delivery, medical diagnostics, and therapeutics based on their unique magnetic, physiochemical, and optical properties [1,2,3,4,5]. Among the various methods for the preparation of Fe3O4 NPs, the solvothermal approach is one of great significance [6,7,8,9]. Fe3O4 NPs were usually composed of multiple singledomain magnetic nanocrystals. The solvothermal method was developed for the preparation of magnetite spheres with strong magnetization through the hydrolysis and reduction of iron chloride in ethylene glycol at high temperatures. Producing Fe3O4 NPs magnetic nanoparticles, followed by chitosan coating. Several research teams have tried to simplify the procedure to obtain Fe3O4 NPs coated with chitosan in one step [16,17,18,19,20]. There are very few reports on the synthesis of magnetic nanoparticles coated with chitosan (CScoated Fe3O4 NPs) by a one-step solvothermal process

Methods

Results

Conclusion