Abstract
Nuclei from synchronized HeLa cells in S-phase continue to synthesize DNA in , vitro at or near the in , vivo replicating sites. Sedimentation of the product in an alkaline sucrose gradient reveals 10 and 24S segments in addition to the 40S non-replicating bulk DNA. Pulse chase experiments indicate that the 10S DNA is a precursor of the 24S product. ATP and the soluble protein fraction from the cytoplasm of S-phase cells support the accumulation of the 24S product.
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