Abstract
A series of chalcones ( 1–9) and pyrazoles ( 10–18) was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis, UV, IR, MS, 1H NMR, 13C NMR, and 2D NMR experiments. Among tested compounds, chalcone 7 exerted the highest activity with an IC 50 value of 0.219 mM, while the most potent pyrazole was 15 (IC 50 value of 0.213 mM).
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